GeneTex Antibodies

Manufacturer: GeneTex Antibodies

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Manufacturer: GeneTex Antibodies

PD-L1 antibody recognizes programmed death-ligand 1 (PD-L1) protein, also known as B7 homolog 1 (B7-H1) and cluster of differentiation 274 (CD274) protein. PD-L1 is found on various cancer cells and transduces immunosuppressive signals by binding to the programmed cell death protein 1 (PD-1) on effector T cells, thereby diminishing immune system attacks on malignant cells. Blocking the interaction between PD-L1 and PD-1 with PD-L1 antibodies is generating great clinical interest as a mode of immunotherapy against a number of cancers.

Manufacturer: GeneTex Antibodies

Ki67 antibody recognizes Ki67 antigen, a nuclear nonhistone protein with a predicted molecular weight of 359 kDa. Ki67 is present during the active phases of the cell cycle and is used clinically as a proliferation marker. Ki67 antibody is used extensively in immunohistochemistry to assess the grade or apparent aggressiveness of various malignancies.

Manufacturer: GeneTex Antibodies

Manufacturer: GeneTex Antibodies

Immunofluorescent analysis of Zika Virus Envelope in mock and zika virus-infected cells. Green: Zika virus Envelope protein monoclonal antibody.

Manufacturer: GeneTex Antibodies

HIF1 alphaantibodyrecognizes HIF1 alpha(HIF1a) protein, which isasubunit of the heterodimerictranscription factor hypoxia-induciblefactor-1 (HIF-1). HIF-1 isamaster regulator of homeostaticadaption to hypoxia(low oxygen supply) in various physiologicaland pathological conditionsincluding normal developmentand cancer.