PD-L1 antibody

Manufacturer: GeneTex Antibodies

HIF1 alphaantibodyrecognizes HIF1 alpha(HIF1a) protein, which isasubunit of the heterodimerictranscription factor hypoxia-induciblefactor-1 (HIF-1). HIF-1 isamaster regulator of homeostaticadaption to hypoxia(low oxygen supply) in various physiologicaland pathological conditionsincluding normal developmentand cancer.

Manufacturer: GeneTex Antibodies

Immunofluorescent analysis of Zika Virus Envelope in mock and zika virus-infected cells. Green: Zika virus Envelope protein monoclonal antibody.

Manufacturer: GeneTex Antibodies

Manufacturer: GeneTex Antibodies

Ki67 antibody recognizes Ki67 antigen, a nuclear nonhistone protein with a predicted molecular weight of 359 kDa. Ki67 is present during the active phases of the cell cycle and is used clinically as a proliferation marker. Ki67 antibody is used extensively in immunohistochemistry to assess the grade or apparent aggressiveness of various malignancies.

Manufacturer: GeneTex Antibodies

PD-L1 antibody recognizes programmed death-ligand 1 (PD-L1) protein, also known as B7 homolog 1 (B7-H1) and cluster of differentiation 274 (CD274) protein. PD-L1 is found on various cancer cells and transduces immunosuppressive signals by binding to the programmed cell death protein 1 (PD-1) on effector T cells, thereby diminishing immune system attacks on malignant cells. Blocking the interaction between PD-L1 and PD-1 with PD-L1 antibodies is generating great clinical interest as a mode of immunotherapy against a number of cancers.

Manufacturer: GeneTex Antibodies

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Manufacturer: GeneTex Antibodies

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).

Manufacturer: GeneTex Antibodies

Influenza A subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. There are 16 different HA antigens (H1-H16) and nine different NA antigens (N1-N9) for Influenza A. The extent of infection into host organisms is determined by HA, which interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues.

Manufacturer: GeneTex Antibodies

Manufacturer: GeneTex Antibodies

Manufacturer: GeneTex Antibodies

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.

Manufacturer: GeneTex Antibodies

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.

Manufacturer: GeneTex Antibodies

TET3 antibody recognizes TET3 protein (predicted molecular weight of 194 kDa), a dioxygenase involved in active DNA demethylation that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and subsequently to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). Like TET1 and TET2, TET3 appears to impact epigenetic regulation of gene expression. It is also involved in early embryogenesis, neuronal function, and other processes.

Manufacturer: GeneTex Antibodies

SOD2 (superoxide dismutase 2, mitochondrial) is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in SOD2 have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of SOD2 results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.

Manufacturer: GeneTex Antibodies

Western blot analysis of Chikungunya Virus NSP2 in Chikungunya viral lysate (0.5 µg) separated by 7.5% SDS-PAGE. Membrane was blotted with Chikungunya Virus NSP2 Monoclonal antibody (Product # MA5-47042) using a dilution of 1:20,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody.