Abbkine Scientific ELISA Kits

Explore the vast range of ELISA Kits from Abbkine Scientific

Human Stereocilin (STRC) ELISA Kit

Manufacturer: Abbkine Scientific

Stereocilin is a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. Defects in STRC are a cause of non-syndromic sensorineural deafness autosomal recessive type 16 (DFNB16) . DFNB16 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

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Human Transforming Growth Factors β2 (TGF-β2) ELISA Kit

Manufacturer: Abbkine Scientific

TGF-β2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes TGF-β2 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in TGF-β2 may be associated with Loeys-Dietz syndrome. TGF-β2 encodes multiple isoforms that may undergo similar proteolytic processing.

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